Coeliac disease

Current Care Summary
1.12.2010
Working group appointed by the Finnish Medical Society Duodecim and the Finnish Society of Gastroenterology

Current Care guideline (in Finnish) «Keliakia»1

Undetected coeliac disease is common, even in elderly people. Anti-transglutaminase, endomysial and deamidated gliadin antibody tests are sensitive and specific. Transglutaminase-specific IgA deposits in mucosal tissue provide the most accurate method of detecting early coeliac disease without villous atrophy. In refractory coeliac disease, the response to diet is lacking. Refractory disease is classified into types I and II. In type II, epithelial T-cells are negative for CD4/CD8 and there is monoclonal T-cell gamma-gene rearrangement, with an increased risk of lymphoma. The EU states that a ‘gluten-free diet’ should contain less than 20mg, and a ‘very low gluten diet’ less than 100mg, of gluten per kilogramme.

Working group appointed by the Finnish Medical Society Duodecim and the Finnish Society of Gastroenterology

Pekka Collin (Chair)

Katri Kaukinen

Markku Mäki

Alpo Vuorio

Consultants:

Kaisa Hervonen

Kaija-Leena Kolho

Sari Mäkinen