Takaisin

Masennuslääke ahdistuneisuushäiriöön

Näytönastekatsaukset
Sami Pirkola
8.1.2020

Näytön aste: A

Masennuslääkkeistä ainakin SSRI -lääkkeet ja venlafaksiini ovat tehokkaita yksittäisten ahdistuneisuushäiriöiden hoidossa.

Perusterveydenhuollon ja psykiatrisen avohoidon potilailla tehdyssä, 541 potilaan 24 viikon lumekontrolloidussa tutkimuksessa «Allgulander C, Hackett D, Salinas E. Venlafaxine e...»10 venlafaksiini oli tehokas yleistyneen ahdistuneisuushäiriön oireisiin. Hitaasti liukeneva venlafaksiini annoksella 150 mg/vrk vähensi Hamiltonin ahdistuneisuusasteikolla (HRSA total) mitattuna ahdistuneisuutta 24 viikon seurannassa lumetta merkittävästi enemmän (-16,4 vs -11,0, p < 0,017).

  • Tutkimuksen laatu: tasokas
  • Sovellettavuus suomalaiseen väestöön: hyvä

Kirjallisuutta

  1. Baldwin D, Bobes J, Stein DJ ym. Paroxetine in social phobia/social anxiety disorder. Randomised, double-blind, placebo-controlled study. Paroxetine Study Group. Br J Psychiatry 1999;175:120-6 «PMID: 10627793»PubMed
  2. Katzelnick DJ, Kobak KA, Greist JH ym. Sertraline for social phobia: a double-blind, placebo-controlled crossover study. Am J Psychiatry 1995;152:1368-71 «PMID: 7653696»PubMed
  3. Schneier FR, Goetz D, Campeas R ym. Placebo-controlled trial of moclobemide in social phobia. Br J Psychiatry 1998;172:70-7 «PMID: 9534836»PubMed
  4. Stein MB, Liebowitz MR, Lydiard RB ym. Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trial. JAMA 1998;280:708-13 «PMID: 9728642»PubMed
  5. Stein MB, Fyer AJ, Davidson JR ym. Fluvoxamine treatment of social phobia (social anxiety disorder): a double-blind, placebo-controlled study. Am J Psychiatry 1999;156:756-60 «PMID: 10327910»PubMed
  6. Pollack MH, Rapaport MH, Clary CM ym. Sertraline treatment of panic disorder: response in patients at risk for poor outcome. J Clin Psychiatry 2000;61:922-7 «PMID: 11206597»PubMed
  7. Boyer W. Serotonin uptake inhibitors are superior to imipramine and alprazolam in alleviating panic attacks: a meta-analysis. Int Clin Psychopharmacol 1995;10:45-9 «PMID: 7622804»PubMed
  8. Clum GA, Clum GA, Surls R. A meta-analysis of treatments for panic disorder. J Consult Clin Psychol 1993;61:317-26 «PMID: 8097212»PubMed
  9. Lepola UM, Wade AG, Leinonen EV ym. A controlled, prospective, 1-year trial of citalopram in the treatment of panic disorder. J Clin Psychiatry 1998;59:528-34 «PMID: 9818634»PubMed
  10. Allgulander C, Hackett D, Salinas E. Venlafaxine extended release (ER) in the treatment of generalised anxiety disorder: twenty-four-week placebo-controlled dose-ranging study. Br J Psychiatry 2001;179:15-22 «PMID: 11435263»PubMed
  11. Loerch B, Graf-Morgenstern M, Hautzinger M ym. Randomised placebo-controlled trial of moclobemide, cognitive-behavioural therapy and their combination in panic disorder with agoraphobia. Br J Psychiatry 1999;174:205-12 «PMID: 10448444»PubMed
  12. Londborg PD, Wolkow R, Smith WT ym. Sertraline in the treatment of panic disorder. A multi-site, double-blind, placebo-controlled, fixed-dose investigation. Br J Psychiatry 1998;173:54-60 «PMID: 9850204»PubMed
  13. Michelson D, Lydiard RB, Pollack MH ym. Outcome assessment and clinical improvement in panic disorder: evidence from a randomized controlled trial of fluoxetine and placebo. The Fluoxetine Panic Disorder Study Group. Am J Psychiatry 1998;155:1570-7 «PMID: 9812120»PubMed
  14. Oehrberg S, Christiansen PE, Behnke K ym. Paroxetine in the treatment of panic disorder. A randomised, double-blind, placebo-controlled study. Br J Psychiatry 1995;167:374-9 «PMID: 7496647»PubMed
  15. Wade AG, Lepola U, Koponen HJ ym. The effect of citalopram in panic disorder. Br J Psychiatry 1997;170:549-53 «PMID: 9330022»PubMed
  16. Rickels K, Downing R, Schweizer E ym. Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam. Arch Gen Psychiatry 1993;50:884-95 «PMID: 8215814»PubMed
  17. Rickels K, Pollack MH, Sheehan DV ym. Efficacy of extended-release venlafaxine in nondepressed outpatients with generalized anxiety disorder. Am J Psychiatry 2000;157:968-74 «PMID: 10831478»PubMed
  18. Michelson D, Allgulander C, Dantendorfer K ym. Efficacy of usual antidepressant dosing regimens of fluoxetine in panic disorder: randomised, placebo-controlled trial. Br J Psychiatry 2001;179:514-8 «PMID: 11731354»PubMed