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Antiviral treatment for the first episode of genital herpes

Evidence summaries
29.12.2016
Editors

Level of evidence: B

Oral acyclovir and valacyclovir appears to be effective for first episode of genital herpes compared with placebo.

Comment: The quality of evidence is downgraded by study limitations (unclear risk of bias).

A Cochrane review «»1 «Heslop R, Roberts H, Flower D et al. Interventions for men and women with their first episode of genital herpes. Cochrane Database Syst Rev 2016;(8):CD010684. »1 included 26 studies with a total of 2084 men and women experiencing their first episode of genital herpes. Oral acyclovir, when compared to placebo, reduced the duration of symptoms (mean difference (MD) -3.22, 95% CI -5.91 to -0.54; 2 trials, I²=52%). Oral valacyclovir showed a similar length of symptom duration when compared to acyclovir in two studies. Two studies reported no evidence of a reduction in the number of median days to recurrence following treatment with oral acyclovir versus placebo.

This document is linked to the following articles:

  • Seksitaudit 1

References

  1. Heslop R, Roberts H, Flower D et al. Interventions for men and women with their first episode of genital herpes. Cochrane Database Syst Rev 2016;(8):CD010684. «PMID: 27575957»PubMed
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