Last reviewed as up-to-date 16.6.2019 • Latest change 16.6.2019
Oral oestrogens appear not to be effective for reducing recurrent urinary tract infections
compared to placebo in postmenopausal women.
A Cochrane review «»1 «Perrotta C, Aznar M, Mejia R, Albert X, Ng CW. Oes...»1 included 4 studies with a total of 2798 women. Oral oestrogens did not reduce UTI
compared to placebo (RR 1.08, 95% CI 0.88 to 1.33, 4 trials, n=2798). Adverse events
were breast tenderness, vaginal bleeding or spotting.
A systematic review and meta-analysis «...»2 of randomized controlled trials showed no decrease of the rate of urinary tract infection
recurrence with oral oestrogens. Neither did another systematic review «...»3 find an effect with oral oestrogens.
Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment).
The following decision support rules contain links to this evidence summary:
This document is linked to the following articles:
- Perrotta C, Aznar M, Mejia R, Albert X, Ng CW. Oestrogens for preventing recurrent
urinary tract infection in postmenopausal women. Cochrane Database Syst Rev 2008 Apr
16;(2):CD005131. «PMID: 18425910»PubMed
- Beerepoot MA, Geerlings SE, van Haarst EP et al. Nonantibiotic prophylaxis for recurrent
urinary tract infections: a systematic review and meta-analysis of randomized controlled
trials. J Urol 2013;190(6):1981-9. «PMID: 23867306»PubMed
- Haugen W, Spigset O. [How to prevent recurrent urinary tract infections after menopause?].
Tidsskr Nor Laegeforen 2015;135(1):42-4. «PMID: 25589128»PubMed