Kohonnut verenpaine, näytönastekatsausten kirjallisuusviitteet
Lisätietoa aiheesta
Käypä hoito -toimitus
21.9.2026
Kirjallisuusviiteluettelosta löytyy koottuna Käypä hoito -suosituksen Kohonnut verenpaine «Kohonnut verenpaine»1 näytönastekatsauksissa arvioitu kirjallisuus.
Kirjallisuutta
- Aburto NJ, Hanson S, Gutierrez H, ym. Effect of increased potassium intake on cardiovascular
risk factors and disease: systematic review and meta-analyses. BMJ 2013;346():f1378
«PMID: 23558164»PubMed
- ACCORD Study Group, Cushman WC, Evans GW, ym. Effects of intensive blood-pressure
control in type 2 diabetes mellitus. N Engl J Med 2010;362(17):1575-85 «PMID: 20228401»PubMed
- ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major
outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme
inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering
Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288(23):2981-97 «PMID: 12479763»PubMed
- Appel LJ, Wright JT Jr, Greene T, ym. Intensive blood-pressure control in hypertensive
chronic kidney disease. N Engl J Med 2010;363(10):918-29 «PMID: 20818902»PubMed
- Beckett N, Peters R, Tuomilehto J, ym. Immediate and late benefits of treating very
elderly people with hypertension: results from active treatment extension to Hypertension
in the Very Elderly randomised controlled trial. BMJ 2011;344():d7541 «PMID: 22218098»PubMed
- Beckett NS, Peters R, Fletcher AE, ym. Treatment of hypertension in patients 80 years
of age or older. N Engl J Med 2008;358(18):1887-98 «PMID: 18378519»PubMed
- Benetos A, Petrovic M, Strandberg T. Hypertension Management in Older and Frail Older
Patients. Circ Res 2019;124(7):1045-1060 «PMID: 30920928»PubMed
- Bi Y, Li M, Liu Y, ym. Intensive Blood-Pressure Control in Patients with Type 2 Diabetes.
N Engl J Med 2025;392(12):1155-1167 «PMID: 39555827»PubMed
- Brenner BM, Cooper ME, de Zeeuw D, ym. Effects of losartan on renal and cardiovascular
outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001;345(12):861-9
«PMID: 11565518»PubMed
- Brunström M, Carlberg B, Kjeldsen SE. Effect of antihypertensive treatment in isolated
systolic hypertension (ISH) - systematic review and meta-analysis of randomised controlled
trials. Blood Press 2023;32(1):2226757 «PMID: 37395100»PubMed
- Cheung AK, Rahman M, Reboussin DM, ym. Effects of Intensive BP Control in CKD. J Am
Soc Nephrol 2017;28(9):2812-2823 «PMID: 28642330»PubMed
- Collins R, MacMahon S. Blood pressure, antihypertensive drug treatment and the risks
of stroke and of coronary heart disease. Br Med Bull 1994;50(2):272-98 «PMID: 8205459»PubMed
- Collins R, Peto R, MacMahon S, ym. Blood pressure, stroke, and coronary heart disease.
Part 2, Short-term reductions in blood pressure: overview of randomised drug trials
in their epidemiological context. Lancet 1990;335(8693):827-38 «PMID: 1969567»PubMed
- Cowell OR, Mistry N, Deighton K, ym. Effects of a Mediterranean diet on blood pressure:
a systematic review and meta-analysis of randomized controlled trials and observational
studies. J Hypertens 2021;39(4):729-739 «PMID: 33060448»PubMed
- Dawson J, Béjot Y, Christensen LM, ym. European Stroke Organisation (ESO) guideline
on pharmacological interventions for long-term secondary prevention after ischaemic
stroke or transient ischaemic attack. Eur Stroke J 2022;7(3):I-II «PMID: 36082250»PubMed
- Diao D, Wright JM, Cundiff DK, ym. Pharmacotherapy for mild hypertension. Cochrane
Database Syst Rev 2012;2012(8):CD006742 «PMID: 22895954»PubMed
- Dickinson HO, Nicolson DJ, Campbell F, ym. Potassium supplementation for the management
of primary hypertension in adults. Cochrane Database Syst Rev 2006;(3):CD004641 «PMID: 16856053»PubMed
- Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic
blood pressure averaging 90 through 114 mm Hg. JAMA 1970;213(7):1143-52 «PMID: 4914579»PubMed
- Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs:
a network meta-analysis. Lancet 2007;369(9557):201-7 «PMID: 17240286»PubMed
- Ettehad D, Emdin CA, Kiran A, ym. Blood pressure lowering for prevention of cardiovascular
disease and death: a systematic review and meta-analysis. Lancet 2016;387(10022):957-967
«PMID: 26724178»PubMed
- Filippini T, Malavolti M, Whelton PK, ym. Blood Pressure Effects of Sodium Reduction:
Dose-Response Meta-Analysis of Experimental Studies. Circulation 2021;143(16):1542-1567
«PMID: 33586450»PubMed
- Filippini T, Naska A, Kasdagli MI, ym. Potassium Intake and Blood Pressure: A Dose-Response
Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc 2020;9(12):e015719
«PMID: 32500831»PubMed
- Filippini T, Violi F, D'Amico R, ym. The effect of potassium supplementation on blood
pressure in hypertensive subjects: A systematic review and meta-analysis. Int J Cardiol
2017;230():127-135 «PMID: 28024910»PubMed
- Filippou CD, Thomopoulos CG, Kouremeti MM, ym. Mediterranean diet and blood pressure
reduction in adults with and without hypertension: A systematic review and meta-analysis
of randomized controlled trials. Clin Nutr 2021;40(5):3191-3200 «PMID: 33581952»PubMed
- Filippou CD, Tsioufis CP, Thomopoulos CG, ym. Dietary Approaches to Stop Hypertension
(DASH) Diet and Blood Pressure Reduction in Adults with and without Hypertension:
A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr 2020;11(5):1150-1160
«PMID: 32330233»PubMed
- Five-year findings of the hypertension detection and follow-up program. I. Reduction
in mortality of persons with high blood pressure, including mild hypertension. Hypertension
Detection and Follow-up Program Cooperative Group. JAMA 1979;242(23):2562-71 «PMID: 490882»PubMed
- Five-year findings of the hypertension detection and follow-up program. III. Reduction
in stroke incidence among persons with high blood pressure. Hypertension Detection
and Follow-up Program Cooperative Group. JAMA 1982;247(5):633-8 «PMID: 7033578»PubMed
- Forette F, Seux ML, Staessen JA, ym. The prevention of dementia with antihypertensive
treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study.
Arch Intern Med 2002;162(18):2046-52 «PMID: 12374512»PubMed
- Fu J, Liu Y, Zhang L, ym. Nonpharmacologic Interventions for Reducing Blood Pressure
in Adults With Prehypertension to Established Hypertension. J Am Heart Assoc 2020;9(19):e016804
«PMID: 32975166»PubMed
- Graudal NA, Hubeck-Graudal T, Jürgens G. Effects of low-sodium diet vs. high-sodium
diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride
(Cochrane Review). Am J Hypertens 2012;25(1):1-15 «PMID: 22068710»PubMed
- Grimm RH Jr, Grandits GA, Cutler JA, ym. Relationships of quality-of-life measures
to long-term lifestyle and drug treatment in the Treatment of Mild Hypertension Study.
Arch Intern Med 1997;157(6):638-48 «PMID: 9080918»PubMed
- Grimm RH Jr, Grandits GA, Prineas RJ, ym. Long-term effects on sexual function of
five antihypertensive drugs and nutritional hygienic treatment in hypertensive men
and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension 1997;29(1 Pt
1):8-14 «PMID: 9039073»PubMed
- Gueyffier F, Bulpitt C, Boissel JP, ym. Antihypertensive drugs in very old people:
a subgroup meta-analysis of randomised controlled trials. INDANA Group. Lancet 1999;353(9155):793-6
«PMID: 10459960»PubMed
- Gupta AK, Dahlof B, Dobson J, ym. Determinants of new-onset diabetes among 19,257
hypertensive patients randomized in the Anglo-Scandinavian Cardiac Outcomes Trial--Blood
Pressure Lowering Arm and the relative influence of antihypertensive medication. Diabetes
Care 2008;31(5):982-8 «PMID: 18235048»PubMed
- Gupta DK, Lewis CE, Varady KA, ym. Effect of Dietary Sodium on Blood Pressure: A Crossover
Trial. JAMA 2023;330(23):2258-2266 «PMID: 37950918»PubMed
- Hanssen H, Boardman H, Deiseroth A, ym. Personalized exercise prescription in the
prevention and treatment of arterial hypertension: a Consensus Document from the European
Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension. Eur
J Prev Cardiol 2022;29(1):205-215 «PMID: 33758927»PubMed
- Hansson L, Zanchetti A, Carruthers SG, ym. Effects of intensive blood-pressure lowering
and low-dose aspirin in patients with hypertension: principal results of the Hypertension
Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998;351(9118):1755-62
«PMID: 9635947»PubMed
- He FJ, Li J, Macgregor GA. Effect of longer-term modest salt reduction on blood pressure.
Cochrane Database Syst Rev 2013;2013(4):CD004937 «PMID: 23633321»PubMed
- He J, Ouyang N, Guo X, ym. Effectiveness of a non-physician community health-care
provider-led intensive blood pressure intervention versus usual care on cardiovascular
disease (CRHCP): an open-label, blinded-endpoint, cluster-randomised trial. Lancet
2023;401(10380):928-938 «PMID: 36871573»PubMed
- Hsu CY, Saver JL, Ovbiagele B, ym. Association Between Magnitude of Differential Blood
Pressure Reduction and Secondary Stroke Prevention: A Meta-analysis and Meta-Regression.
JAMA Neurol 2023;80(5):506-515 «PMID: 36939729»PubMed
- Hypertension Detection and Follow-up Program Cooperative Group. The effect of treatment
on mortality in "mild" hypertension: results of the hypertension detection and follow-up
program. N Engl J Med 1982;307(16):976-80 «PMID: 7110301»PubMed
- Iadecola C, Gottesman RF. Neurovascular and Cognitive Dysfunction in Hypertension.
Circ Res 2019;124(7):1025-1044 «PMID: 30920929»PubMed
- Khan N, McAlister FA. Re-examining the efficacy of beta-blockers for the treatment
of hypertension: a meta-analysis. CMAJ 2006;174(12):1737-42 «PMID: 16754904»PubMed
- Kjeldsen SE, Dahlöf B, Devereux RB, ym. Effects of losartan on cardiovascular morbidity
and mortality in patients with isolated systolic hypertension and left ventricular
hypertrophy: a Losartan Intervention for Endpoint Reduction (LIFE) substudy. JAMA
2002;288(12):1491-8 «PMID: 12243636»PubMed
- Klahr S, Levey AS, Beck GJ, ym. The effects of dietary protein restriction and blood-pressure
control on the progression of chronic renal disease. Modification of Diet in Renal
Disease Study Group. N Engl J Med 1994;330(13):877-84 «PMID: 8114857»PubMed
- Kostis JB, Wilson AC, Freudenberger RS, ym. Long-term effect of diuretic-based therapy
on fatal outcomes in subjects with isolated systolic hypertension with and without
diabetes. Am J Cardiol 2005;95(1):29-35 «PMID: 15619390»PubMed
- Ku E, McCulloch CE, Inker LA, ym. Intensive BP Control in Patients with CKD and Risk
for Adverse Outcomes. J Am Soc Nephrol 2023;34(3):385-393 «PMID: 36735510»PubMed
- Law MR, Frost CD, Wald NJ. By how much does dietary salt reduction lower blood pressure?
III--Analysis of data from trials of salt reduction. BMJ 1991;302(6780):819-24 «PMID: 1827353»PubMed
- Law MR, Frost CD, Wald NJ. By how much does dietary salt reduction lower blood pressure?
I--Analysis of observational data among populations. BMJ 1991;302(6780):811-5 «PMID: 2025703»PubMed
- Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention
of cardiovascular disease: meta-analysis of 147 randomised trials in the context of
expectations from prospective epidemiological studies. BMJ 2009;338():b1665 «PMID: 19454737»PubMed
- Law MR, Wald NJ, Morris JK, ym. Value of low dose combination treatment with blood
pressure lowering drugs: analysis of 354 randomised trials. BMJ 2003;326(7404):1427
«PMID: 12829555»PubMed
- Lawes CM, Bennett DA, Feigin VL, ym. Blood pressure and stroke: an overview of published
reviews. Stroke 2004;35(3):776-85 «PMID: 14976329»PubMed
- Lewis EJ, Hunsicker LG, Clarke WR, ym. Renoprotective effect of the angiotensin-receptor
antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl
J Med 2001;345(12):851-60 «PMID: 11565517»PubMed
- Li S, Peng Y, Li Y, ym. Effects of Intensive Blood Pressure Control in Patients With
Frailty: A Post Hoc Analysis From ESPRIT. J Am Coll Cardiol 2026;87(1):4-16 «PMID: 41091084»PubMed
- Li Z, Li Y, Liu Y, ym. Comparative risk of new-onset diabetes mellitus for antihypertensive
drugs: A network meta-analysis. J Clin Hypertens (Greenwich) 2017;19(12):1348-1356
«PMID: 29067768»PubMed
- Lindholm LH, Carlberg B, Samuelsson O. Should beta blockers remain first choice in
the treatment of primary hypertension? A meta-analysis. Lancet 2005;366(9496):1545-53
«PMID: 16257341»PubMed
- Lipsitz LA. A 91-year-old woman with difficult-to-control hypertension: a clinical
review. JAMA 2013;310(12):1274-80 «PMID: 24065014»PubMed
- Lithell H, Hansson L, Skoog I, ym. The Study on Cognition and Prognosis in the Elderly
(SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens
2003;21(5):875-86 «PMID: 12714861»PubMed
- Liu J, Li Y, Ge J, ym. Lowering systolic blood pressure to less than 120 mm Hg versus
less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes
or previous stroke: an open-label, blinded-outcome, randomised trial. Lancet 2024;404(10449):245-255
«PMID: 38945140»PubMed
- Liu L, Zhang Y, Liu G, ym. The Felodipine Event Reduction (FEVER) Study: a randomized
long-term placebo-controlled trial in Chinese hypertensive patients. J Hypertens 2005;23(12):2157-72
«PMID: 16269957»PubMed
- Livingston G, Huntley J, Liu KY, ym. Dementia prevention, intervention, and care:
2024 report of the Lancet standing Commission. Lancet 2024;404(10452):572-628 «PMID: 39096926»PubMed
- Lonn EM, Bosch J, López-Jaramillo P, ym. Blood-Pressure Lowering in Intermediate-Risk
Persons without Cardiovascular Disease. N Engl J Med 2016;374(21):2009-20 «PMID: 27041480»PubMed
- Lv J, Ehteshami P, Sarnak MJ, ym. Effects of intensive blood pressure lowering on
the progression of chronic kidney disease: a systematic review and meta-analysis.
CMAJ 2013;185(11):949-57 «PMID: 23798459»PubMed
- Malhotra R, Nguyen HA, Benavente O, ym. Association Between More Intensive vs Less
Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease
Stages 3 to 5: A Systematic Review and Meta-analysis. JAMA Intern Med 2017;177(10):1498-1505
«PMID: 28873137»PubMed
- Materson BJ, Reda DJ, Cushman WC, ym. Single-drug therapy for hypertension in men.
A comparison of six antihypertensive agents with placebo. The Department of Veterans
Affairs Cooperative Study Group on Antihypertensive Agents. N Engl J Med 1993;328(13):914-21
«PMID: 8446138»PubMed
- . Medical Research Council trial of treatment of hypertension in older adults: principal
results. MRC Working Party. BMJ 1992;304(6824):405-12 «PMID: 1445513»PubMed
- Midgley JP, Matthew AG, Greenwood CM, ym. Effect of reduced dietary sodium on blood
pressure: a meta-analysis of randomized controlled trials. JAMA 1996;275(20):1590-7
«PMID: 8622251»PubMed
- Moll van Charante EP, Richard E, Eurelings LS, ym. Effectiveness of a 6-year multidomain
vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled
trial. Lancet 2016;388(10046):797-805 «PMID: 27474376»PubMed
- Morita H, Abe M, Suematsu Y, ym. Resistance exercise has an antihypertensive effect
comparable to that of aerobic exercise in hypertensive patients: a meta-analysis of
randomized controlled trials. Hypertens Res 2025;48(2):733-743 «PMID: 39609644»PubMed
- MRC trial of treatment of mild hypertension: principal results. Medical Research Council
Working Party. Br Med J (Clin Res Ed) 1985;291(6488):97-104 «PMID: 2861880»PubMed
- Neaton JD, Grimm RH Jr, Prineas RJ, ym. Treatment of Mild Hypertension Study. Final
results. Treatment of Mild Hypertension Study Research Group. JAMA 1993;270(6):713-24
«PMID: 8336373»PubMed
- Oza R, Aggarwal P, Bhardwaj P, ym. Efficacy and Safety of ARB-Based Combination Therapies
for Treatment of Hypertension: A Systematic Review and Meta-analyses. High Blood Press
Cardiovasc Prev 2026;33(3):257-268 «PMID: 41543654»PubMed
- Pahor M, Psaty BM, Alderman MH, ym. Health outcomes associated with calcium antagonists
compared with other first-line antihypertensive therapies: a meta-analysis of randomised
controlled trials. Lancet 2000;356(9246):1949-54 «PMID: 11130522»PubMed
- Patel A, ADVANCE Collaborative Group, MacMahon S, ym. Effects of a fixed combination
of perindopril and indapamide on macrovascular and microvascular outcomes in patients
with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial.
Lancet 2007;370(9590):829-40 «PMID: 17765963»PubMed
- Peters R, Beckett N, Forette F, ym. Incident dementia and blood pressure lowering
in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG):
a double-blind, placebo controlled trial. Lancet Neurol 2008;7(8):683-9 «PMID: 18614402»PubMed
- Philipp T, Anlauf M, Distler A, ym. Randomised, double blind, multicentre comparison
of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive
treatment: results of the HANE study. HANE Trial Research Group. BMJ 1997;315(7101):154-9
«PMID: 9251545»PubMed
- Prevention of stroke by antihypertensive drug treatment in older persons with isolated
systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program
(SHEP). SHEP Cooperative Research Group. JAMA 1991;265(24):3255-64 «PMID: 2046107»PubMed
- PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering
regimen among 6,105 individuals with previous stroke or transient ischaemic attack.
Lancet 2001;358(9287):1033-41 «PMID: 11589932»PubMed
- Psaty BM, Lumley T, Furberg CD, ym. Health outcomes associated with various antihypertensive
therapies used as first-line agents: a network meta-analysis. JAMA 2003;289(19):2534-44
«PMID: 12759325»PubMed
- Psaty BM, Smith NL, Siscovick DS, ym. Health outcomes associated with antihypertensive
therapies used as first-line agents. A systematic review and meta-analysis. JAMA 1997;277(9):739-45
«PMID: 9042847»PubMed
- Rahman F, McEvoy JW, Ohkuma T, ym. Effects of Blood Pressure Lowering on Clinical
Outcomes According to Baseline Blood Pressure and Cardiovascular Risk in Patients
With Type 2 Diabetes Mellitus. Hypertension 2019;73(6):1291-1299 «PMID: 31030606»PubMed
- Rouch L, Cestac P, Hanon O, ym. Antihypertensive drugs, prevention of cognitive decline
and dementia: a systematic review of observational studies, randomized controlled
trials and meta-analyses, with discussion of potential mechanisms. CNS Drugs 2015;29(2):113-30
«PMID: 25700645»PubMed
- Ruggenenti P, Perna A, Loriga G, ym. Blood-pressure control for renoprotection in
patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised
controlled trial. Lancet 2005;365(9463):939-46 «PMID: 15766995»PubMed
- Sarnak MJ, Greene T, Wang X, ym. The effect of a lower target blood pressure on the
progression of kidney disease: long-term follow-up of the modification of diet in
renal disease study. Ann Intern Med 2005;142(5):342-51 «PMID: 15738453»PubMed
- Schall P, Wehling M. Treatment of arterial hypertension in the very elderly: a meta-analysis
of clinical trials. Arzneimittelforschung 2011;61(4):221-8 «PMID: 21650080»PubMed
- Schrader J, Lüders S, Kulschewski A, ym. Morbidity and Mortality After Stroke, Eprosartan
Compared with Nitrendipine for Secondary Prevention: principal results of a prospective
randomized controlled study (MOSES). Stroke 2005;36(6):1218-26 «PMID: 15879332»PubMed
- SPRINT MIND Investigators for the SPRINT Research Group, Williamson JD, Pajewski NM,
ym. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A
Randomized Clinical Trial. JAMA 2019;321(6):553-561 «PMID: 30688979»PubMed
- SPRINT Research Group, Wright JT Jr, Williamson JD, ym. A Randomized Trial of Intensive
versus Standard Blood-Pressure Control. N Engl J Med 2015;373(22):2103-16 «PMID: 26551272»PubMed
- SPS3 Study Group, Benavente OR, Coffey CS, ym. Blood-pressure targets in patients
with recent lacunar stroke: the SPS3 randomised trial. Lancet 2013;382(9891):507-15
«PMID: 23726159»PubMed
- Staessen JA, Fagard R, Thijs L, ym. Randomised double-blind comparison of placebo
and active treatment for older patients with isolated systolic hypertension. The Systolic
Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 1997;350(9080):757-64
«PMID: 9297994»PubMed
- Staessen JA, Gasowski J, Wang JG, ym. Risks of untreated and treated isolated systolic
hypertension in the elderly: meta-analysis of outcome trials. Lancet 2000;355(9207):865-72
«PMID: 10752701»PubMed
- Steiner T, Purrucker JC, Aguiar de Sousa D, ym. European Stroke Organisation (ESO)
and European Association of Neurosurgical Societies (EANS) guideline on stroke due
to spontaneous intracerebral haemorrhage. Eur Stroke J 2025;10(4):1007-1086 «PMID: 40401775»PubMed
- Strandberg T. Iäkkään verenpaine. Duodecim 2024;140:403-410
- Strandberg TE, Benetos A, Petrovic M. Editorial: Incident Dementia in Trials of Antihypertensive
Treatments. J Nutr Health Aging 2019;23(10):914-915 «PMID: 31781718»PubMed
- Supiano MA, Ascher SB, Rich MW. Hypertension in the Oldest Old. JACC Adv 2025;4(12
Pt 1):102306 «PMID: 41231192»PubMed
- Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular
Disease (TRANSCEND) Investigators, Yusuf S, Teo K, ym. Effects of the angiotensin-receptor
blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting
enzyme inhibitors: a randomised controlled trial. Lancet 2008;372(9644):1174-83 «PMID: 18757085»PubMed
- The Australian therapeutic trial in mild hypertension. Report by the Management Committee.
Lancet 1980;1(8181):1261-7 «PMID: 6104081»PubMed
- Blood Pressure Lowering Treatment Trialists' Collaboration. Pharmacological blood
pressure lowering for primary and secondary prevention of cardiovascular disease across
different levels of blood pressure: an individual participant-level data meta-analysis.
Lancet 2021;397(10285):1625-1636 «PMID: 33933205»PubMed
- Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome
incidence in hypertension: 7. Effects of more vs. less intensive blood pressure lowering
and different achieved blood pressure levels - updated overview and meta-analyses
of randomized trials. J Hypertens 2016;34(4):613-22 «PMID: 26848994»PubMed
- Thomopoulos C, Parati G, Zanchetti A. Effects of blood-pressure-lowering treatment
in hypertension: 9. Discontinuations for adverse events attributed to different classes
of antihypertensive drugs: meta-analyses of randomized trials. J Hypertens 2016;34(10):1921-32
«PMID: 27454050»PubMed
- Thomopoulos C, Parati G, Zanchetti A. Effects of blood-pressure-lowering treatment
on outcome incidence. 12. Effects in individuals with high-normal and normal blood
pressure: overview and meta-analyses of randomized trials. J Hypertens 2017;35(11):2150-2160
«PMID: 28858984»PubMed
- Turnbull F, Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of
different blood-pressure-lowering regimens on major cardiovascular events: results
of prospectively-designed overviews of randomised trials. Lancet 2003;362(9395):1527-35
«PMID: 14615107»PubMed
- Tzourio C, Anderson C, Chapman N, ym. Effects of blood pressure lowering with perindopril
and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular
disease. Arch Intern Med 2003;163(9):1069-75 «PMID: 12742805»PubMed
- Verdecchia P, Staessen JA, Angeli F, ym. Usual versus tight control of systolic blood
pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised
trial. Lancet 2009;374(9689):525-33 «PMID: 19683638»PubMed
- Wald DS, Law M, Morris JK, ym. Combination therapy versus monotherapy in reducing
blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med 2009;122(3):290-300
«PMID: 19272490»PubMed
- Warwick J, Falaschetti E, Rockwood K, ym. No evidence that frailty modifies the positive
impact of antihypertensive treatment in very elderly people: an investigation of the
impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial
(HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people
with hypertension aged 80 and over. BMC Med 2015;13():78 «PMID: 25880068»PubMed
- Whelton PK, He J, Cutler JA, ym. Effects of oral potassium on blood pressure. Meta-analysis
of randomized controlled clinical trials. JAMA 1997;277(20):1624-32 «PMID: 9168293»PubMed
- Williamson JD, Supiano MA, Applegate WB, ym. Intensive vs Standard Blood Pressure
Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized
Clinical Trial. JAMA 2016;315(24):2673-82 «PMID: 27195814»PubMed
- Wiysonge CS, Bradley H, Mayosi BM, ym. Beta-blockers for hypertension. Cochrane Database
Syst Rev 2007;(1):CD002003 «PMID: 17253471»PubMed
- Wright JM, Lee CH, Chambers GK. Systematic review of antihypertensive therapies: does
the evidence assist in choosing a first-line drug? CMAJ 1999;161(1):25-32 «PMID: 10420860»PubMed
- Wright JT Jr, Bakris G, Greene T, ym. Effect of blood pressure lowering and antihypertensive
drug class on progression of hypertensive kidney disease: results from the AASK trial.
JAMA 2002;288(19):2421-31 «PMID: 12435255»PubMed
- Yusuf S, Diener HC, Sacco RL, ym. Telmisartan to prevent recurrent stroke and cardiovascular
events. N Engl J Med 2008;359(12):1225-37 «PMID: 18753639»PubMed
- Zhang W, Zhang S, Deng Y, ym. Trial of Intensive Blood-Pressure Control in Older Patients
with Hypertension. N Engl J Med 2021;385(14):1268-1279 «PMID: 34491661»PubMed
- Zhang Y, Zhang X, Liu L ym. Is a systolic blood pressure target 140 mmHg indicated
in all hypertensives? Subgroup analyses of findings from the randomized FEVER trial.
Eur Heart J 2011;32:1500-8
- Zhong XL, Dong Y, Xu W, ym. Role of Blood Pressure Management in Stroke Prevention:
A Systematic Review and Network Meta-Analysis of 93 Randomized Controlled Trials.
J Stroke 2021;23(1):1-11 «PMID: 33600699»PubMed
Artikkelin tunnus: nix02845 (040.010)
© 2026 Suomalainen Lääkäriseura Duodecim