Takaisin Tulosta

Kohonnut verenpaine, näytönastekatsausten kirjallisuusviitteet

Lisätietoa aiheesta
Käypä hoito -toimitus
21.9.2026

Kirjallisuusviiteluettelosta löytyy koottuna Käypä hoito -suosituksen Kohonnut verenpaine «Kohonnut verenpaine»1 näytönastekatsauksissa arvioitu kirjallisuus.

Kirjallisuutta

  1. Aburto NJ, Hanson S, Gutierrez H, ym. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ 2013;346():f1378 «PMID: 23558164»PubMed
  2. ACCORD Study Group, Cushman WC, Evans GW, ym. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 2010;362(17):1575-85 «PMID: 20228401»PubMed
  3. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288(23):2981-97 «PMID: 12479763»PubMed
  4. Appel LJ, Wright JT Jr, Greene T, ym. Intensive blood-pressure control in hypertensive chronic kidney disease. N Engl J Med 2010;363(10):918-29 «PMID: 20818902»PubMed
  5. Beckett N, Peters R, Tuomilehto J, ym. Immediate and late benefits of treating very elderly people with hypertension: results from active treatment extension to Hypertension in the Very Elderly randomised controlled trial. BMJ 2011;344():d7541 «PMID: 22218098»PubMed
  6. Beckett NS, Peters R, Fletcher AE, ym. Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008;358(18):1887-98 «PMID: 18378519»PubMed
  7. Benetos A, Petrovic M, Strandberg T. Hypertension Management in Older and Frail Older Patients. Circ Res 2019;124(7):1045-1060 «PMID: 30920928»PubMed
  8. Bi Y, Li M, Liu Y, ym. Intensive Blood-Pressure Control in Patients with Type 2 Diabetes. N Engl J Med 2025;392(12):1155-1167 «PMID: 39555827»PubMed
  9. Brenner BM, Cooper ME, de Zeeuw D, ym. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001;345(12):861-9 «PMID: 11565518»PubMed
  10. Brunström M, Carlberg B, Kjeldsen SE. Effect of antihypertensive treatment in isolated systolic hypertension (ISH) - systematic review and meta-analysis of randomised controlled trials. Blood Press 2023;32(1):2226757 «PMID: 37395100»PubMed
  11. Cheung AK, Rahman M, Reboussin DM, ym. Effects of Intensive BP Control in CKD. J Am Soc Nephrol 2017;28(9):2812-2823 «PMID: 28642330»PubMed
  12. Collins R, MacMahon S. Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease. Br Med Bull 1994;50(2):272-98 «PMID: 8205459»PubMed
  13. Collins R, Peto R, MacMahon S, ym. Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990;335(8693):827-38 «PMID: 1969567»PubMed
  14. Cowell OR, Mistry N, Deighton K, ym. Effects of a Mediterranean diet on blood pressure: a systematic review and meta-analysis of randomized controlled trials and observational studies. J Hypertens 2021;39(4):729-739 «PMID: 33060448»PubMed
  15. Dawson J, Béjot Y, Christensen LM, ym. European Stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack. Eur Stroke J 2022;7(3):I-II «PMID: 36082250»PubMed
  16. Diao D, Wright JM, Cundiff DK, ym. Pharmacotherapy for mild hypertension. Cochrane Database Syst Rev 2012;2012(8):CD006742 «PMID: 22895954»PubMed
  17. Dickinson HO, Nicolson DJ, Campbell F, ym. Potassium supplementation for the management of primary hypertension in adults. Cochrane Database Syst Rev 2006;(3):CD004641 «PMID: 16856053»PubMed
  18. Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA 1970;213(7):1143-52 «PMID: 4914579»PubMed
  19. Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet 2007;369(9557):201-7 «PMID: 17240286»PubMed
  20. Ettehad D, Emdin CA, Kiran A, ym. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 2016;387(10022):957-967 «PMID: 26724178»PubMed
  21. Filippini T, Malavolti M, Whelton PK, ym. Blood Pressure Effects of Sodium Reduction: Dose-Response Meta-Analysis of Experimental Studies. Circulation 2021;143(16):1542-1567 «PMID: 33586450»PubMed
  22. Filippini T, Naska A, Kasdagli MI, ym. Potassium Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc 2020;9(12):e015719 «PMID: 32500831»PubMed
  23. Filippini T, Violi F, D'Amico R, ym. The effect of potassium supplementation on blood pressure in hypertensive subjects: A systematic review and meta-analysis. Int J Cardiol 2017;230():127-135 «PMID: 28024910»PubMed
  24. Filippou CD, Thomopoulos CG, Kouremeti MM, ym. Mediterranean diet and blood pressure reduction in adults with and without hypertension: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr 2021;40(5):3191-3200 «PMID: 33581952»PubMed
  25. Filippou CD, Tsioufis CP, Thomopoulos CG, ym. Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure Reduction in Adults with and without Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr 2020;11(5):1150-1160 «PMID: 32330233»PubMed
  26. Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group. JAMA 1979;242(23):2562-71 «PMID: 490882»PubMed
  27. Five-year findings of the hypertension detection and follow-up program. III. Reduction in stroke incidence among persons with high blood pressure. Hypertension Detection and Follow-up Program Cooperative Group. JAMA 1982;247(5):633-8 «PMID: 7033578»PubMed
  28. Forette F, Seux ML, Staessen JA, ym. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002;162(18):2046-52 «PMID: 12374512»PubMed
  29. Fu J, Liu Y, Zhang L, ym. Nonpharmacologic Interventions for Reducing Blood Pressure in Adults With Prehypertension to Established Hypertension. J Am Heart Assoc 2020;9(19):e016804 «PMID: 32975166»PubMed
  30. Graudal NA, Hubeck-Graudal T, Jürgens G. Effects of low-sodium diet vs. high-sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride (Cochrane Review). Am J Hypertens 2012;25(1):1-15 «PMID: 22068710»PubMed
  31. Grimm RH Jr, Grandits GA, Cutler JA, ym. Relationships of quality-of-life measures to long-term lifestyle and drug treatment in the Treatment of Mild Hypertension Study. Arch Intern Med 1997;157(6):638-48 «PMID: 9080918»PubMed
  32. Grimm RH Jr, Grandits GA, Prineas RJ, ym. Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension 1997;29(1 Pt 1):8-14 «PMID: 9039073»PubMed
  33. Gueyffier F, Bulpitt C, Boissel JP, ym. Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials. INDANA Group. Lancet 1999;353(9155):793-6 «PMID: 10459960»PubMed
  34. Gupta AK, Dahlof B, Dobson J, ym. Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the Anglo-Scandinavian Cardiac Outcomes Trial--Blood Pressure Lowering Arm and the relative influence of antihypertensive medication. Diabetes Care 2008;31(5):982-8 «PMID: 18235048»PubMed
  35. Gupta DK, Lewis CE, Varady KA, ym. Effect of Dietary Sodium on Blood Pressure: A Crossover Trial. JAMA 2023;330(23):2258-2266 «PMID: 37950918»PubMed
  36. Hanssen H, Boardman H, Deiseroth A, ym. Personalized exercise prescription in the prevention and treatment of arterial hypertension: a Consensus Document from the European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension. Eur J Prev Cardiol 2022;29(1):205-215 «PMID: 33758927»PubMed
  37. Hansson L, Zanchetti A, Carruthers SG, ym. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998;351(9118):1755-62 «PMID: 9635947»PubMed
  38. He FJ, Li J, Macgregor GA. Effect of longer-term modest salt reduction on blood pressure. Cochrane Database Syst Rev 2013;2013(4):CD004937 «PMID: 23633321»PubMed
  39. He J, Ouyang N, Guo X, ym. Effectiveness of a non-physician community health-care provider-led intensive blood pressure intervention versus usual care on cardiovascular disease (CRHCP): an open-label, blinded-endpoint, cluster-randomised trial. Lancet 2023;401(10380):928-938 «PMID: 36871573»PubMed
  40. Hsu CY, Saver JL, Ovbiagele B, ym. Association Between Magnitude of Differential Blood Pressure Reduction and Secondary Stroke Prevention: A Meta-analysis and Meta-Regression. JAMA Neurol 2023;80(5):506-515 «PMID: 36939729»PubMed
  41. Hypertension Detection and Follow-up Program Cooperative Group. The effect of treatment on mortality in "mild" hypertension: results of the hypertension detection and follow-up program. N Engl J Med 1982;307(16):976-80 «PMID: 7110301»PubMed
  42. Iadecola C, Gottesman RF. Neurovascular and Cognitive Dysfunction in Hypertension. Circ Res 2019;124(7):1025-1044 «PMID: 30920929»PubMed
  43. Khan N, McAlister FA. Re-examining the efficacy of beta-blockers for the treatment of hypertension: a meta-analysis. CMAJ 2006;174(12):1737-42 «PMID: 16754904»PubMed
  44. Kjeldsen SE, Dahlöf B, Devereux RB, ym. Effects of losartan on cardiovascular morbidity and mortality in patients with isolated systolic hypertension and left ventricular hypertrophy: a Losartan Intervention for Endpoint Reduction (LIFE) substudy. JAMA 2002;288(12):1491-8 «PMID: 12243636»PubMed
  45. Klahr S, Levey AS, Beck GJ, ym. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group. N Engl J Med 1994;330(13):877-84 «PMID: 8114857»PubMed
  46. Kostis JB, Wilson AC, Freudenberger RS, ym. Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes. Am J Cardiol 2005;95(1):29-35 «PMID: 15619390»PubMed
  47. Ku E, McCulloch CE, Inker LA, ym. Intensive BP Control in Patients with CKD and Risk for Adverse Outcomes. J Am Soc Nephrol 2023;34(3):385-393 «PMID: 36735510»PubMed
  48. Law MR, Frost CD, Wald NJ. By how much does dietary salt reduction lower blood pressure? III--Analysis of data from trials of salt reduction. BMJ 1991;302(6780):819-24 «PMID: 1827353»PubMed
  49. Law MR, Frost CD, Wald NJ. By how much does dietary salt reduction lower blood pressure? I--Analysis of observational data among populations. BMJ 1991;302(6780):811-5 «PMID: 2025703»PubMed
  50. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009;338():b1665 «PMID: 19454737»PubMed
  51. Law MR, Wald NJ, Morris JK, ym. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ 2003;326(7404):1427 «PMID: 12829555»PubMed
  52. Lawes CM, Bennett DA, Feigin VL, ym. Blood pressure and stroke: an overview of published reviews. Stroke 2004;35(3):776-85 «PMID: 14976329»PubMed
  53. Lewis EJ, Hunsicker LG, Clarke WR, ym. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001;345(12):851-60 «PMID: 11565517»PubMed
  54. Li S, Peng Y, Li Y, ym. Effects of Intensive Blood Pressure Control in Patients With Frailty: A Post Hoc Analysis From ESPRIT. J Am Coll Cardiol 2026;87(1):4-16 «PMID: 41091084»PubMed
  55. Li Z, Li Y, Liu Y, ym. Comparative risk of new-onset diabetes mellitus for antihypertensive drugs: A network meta-analysis. J Clin Hypertens (Greenwich) 2017;19(12):1348-1356 «PMID: 29067768»PubMed
  56. Lindholm LH, Carlberg B, Samuelsson O. Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis. Lancet 2005;366(9496):1545-53 «PMID: 16257341»PubMed
  57. Lipsitz LA. A 91-year-old woman with difficult-to-control hypertension: a clinical review. JAMA 2013;310(12):1274-80 «PMID: 24065014»PubMed
  58. Lithell H, Hansson L, Skoog I, ym. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 2003;21(5):875-86 «PMID: 12714861»PubMed
  59. Liu J, Li Y, Ge J, ym. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial. Lancet 2024;404(10449):245-255 «PMID: 38945140»PubMed
  60. Liu L, Zhang Y, Liu G, ym. The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients. J Hypertens 2005;23(12):2157-72 «PMID: 16269957»PubMed
  61. Livingston G, Huntley J, Liu KY, ym. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet 2024;404(10452):572-628 «PMID: 39096926»PubMed
  62. Lonn EM, Bosch J, López-Jaramillo P, ym. Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease. N Engl J Med 2016;374(21):2009-20 «PMID: 27041480»PubMed
  63. Lv J, Ehteshami P, Sarnak MJ, ym. Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis. CMAJ 2013;185(11):949-57 «PMID: 23798459»PubMed
  64. Malhotra R, Nguyen HA, Benavente O, ym. Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis. JAMA Intern Med 2017;177(10):1498-1505 «PMID: 28873137»PubMed
  65. Materson BJ, Reda DJ, Cushman WC, ym. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. N Engl J Med 1993;328(13):914-21 «PMID: 8446138»PubMed
  66. . Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party. BMJ 1992;304(6824):405-12 «PMID: 1445513»PubMed
  67. Midgley JP, Matthew AG, Greenwood CM, ym. Effect of reduced dietary sodium on blood pressure: a meta-analysis of randomized controlled trials. JAMA 1996;275(20):1590-7 «PMID: 8622251»PubMed
  68. Moll van Charante EP, Richard E, Eurelings LS, ym. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet 2016;388(10046):797-805 «PMID: 27474376»PubMed
  69. Morita H, Abe M, Suematsu Y, ym. Resistance exercise has an antihypertensive effect comparable to that of aerobic exercise in hypertensive patients: a meta-analysis of randomized controlled trials. Hypertens Res 2025;48(2):733-743 «PMID: 39609644»PubMed
  70. MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party. Br Med J (Clin Res Ed) 1985;291(6488):97-104 «PMID: 2861880»PubMed
  71. Neaton JD, Grimm RH Jr, Prineas RJ, ym. Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group. JAMA 1993;270(6):713-24 «PMID: 8336373»PubMed
  72. Oza R, Aggarwal P, Bhardwaj P, ym. Efficacy and Safety of ARB-Based Combination Therapies for Treatment of Hypertension: A Systematic Review and Meta-analyses. High Blood Press Cardiovasc Prev 2026;33(3):257-268 «PMID: 41543654»PubMed
  73. Pahor M, Psaty BM, Alderman MH, ym. Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials. Lancet 2000;356(9246):1949-54 «PMID: 11130522»PubMed
  74. Patel A, ADVANCE Collaborative Group, MacMahon S, ym. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet 2007;370(9590):829-40 «PMID: 17765963»PubMed
  75. Peters R, Beckett N, Forette F, ym. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol 2008;7(8):683-9 «PMID: 18614402»PubMed
  76. Philipp T, Anlauf M, Distler A, ym. Randomised, double blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study. HANE Trial Research Group. BMJ 1997;315(7101):154-9 «PMID: 9251545»PubMed
  77. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA 1991;265(24):3255-64 «PMID: 2046107»PubMed
  78. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001;358(9287):1033-41 «PMID: 11589932»PubMed
  79. Psaty BM, Lumley T, Furberg CD, ym. Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA 2003;289(19):2534-44 «PMID: 12759325»PubMed
  80. Psaty BM, Smith NL, Siscovick DS, ym. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. JAMA 1997;277(9):739-45 «PMID: 9042847»PubMed
  81. Rahman F, McEvoy JW, Ohkuma T, ym. Effects of Blood Pressure Lowering on Clinical Outcomes According to Baseline Blood Pressure and Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus. Hypertension 2019;73(6):1291-1299 «PMID: 31030606»PubMed
  82. Rouch L, Cestac P, Hanon O, ym. Antihypertensive drugs, prevention of cognitive decline and dementia: a systematic review of observational studies, randomized controlled trials and meta-analyses, with discussion of potential mechanisms. CNS Drugs 2015;29(2):113-30 «PMID: 25700645»PubMed
  83. Ruggenenti P, Perna A, Loriga G, ym. Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial. Lancet 2005;365(9463):939-46 «PMID: 15766995»PubMed
  84. Sarnak MJ, Greene T, Wang X, ym. The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modification of diet in renal disease study. Ann Intern Med 2005;142(5):342-51 «PMID: 15738453»PubMed
  85. Schall P, Wehling M. Treatment of arterial hypertension in the very elderly: a meta-analysis of clinical trials. Arzneimittelforschung 2011;61(4):221-8 «PMID: 21650080»PubMed
  86. Schrader J, Lüders S, Kulschewski A, ym. Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). Stroke 2005;36(6):1218-26 «PMID: 15879332»PubMed
  87. SPRINT MIND Investigators for the SPRINT Research Group, Williamson JD, Pajewski NM, ym. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. JAMA 2019;321(6):553-561 «PMID: 30688979»PubMed
  88. SPRINT Research Group, Wright JT Jr, Williamson JD, ym. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2015;373(22):2103-16 «PMID: 26551272»PubMed
  89. SPS3 Study Group, Benavente OR, Coffey CS, ym. Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. Lancet 2013;382(9891):507-15 «PMID: 23726159»PubMed
  90. Staessen JA, Fagard R, Thijs L, ym. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 1997;350(9080):757-64 «PMID: 9297994»PubMed
  91. Staessen JA, Gasowski J, Wang JG, ym. Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials. Lancet 2000;355(9207):865-72 «PMID: 10752701»PubMed
  92. Steiner T, Purrucker JC, Aguiar de Sousa D, ym. European Stroke Organisation (ESO) and European Association of Neurosurgical Societies (EANS) guideline on stroke due to spontaneous intracerebral haemorrhage. Eur Stroke J 2025;10(4):1007-1086 «PMID: 40401775»PubMed
  93. Strandberg T. Iäkkään verenpaine. Duodecim 2024;140:403-410
  94. Strandberg TE, Benetos A, Petrovic M. Editorial: Incident Dementia in Trials of Antihypertensive Treatments. J Nutr Health Aging 2019;23(10):914-915 «PMID: 31781718»PubMed
  95. Supiano MA, Ascher SB, Rich MW. Hypertension in the Oldest Old. JACC Adv 2025;4(12 Pt 1):102306 «PMID: 41231192»PubMed
  96. Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators, Yusuf S, Teo K, ym. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial. Lancet 2008;372(9644):1174-83 «PMID: 18757085»PubMed
  97. The Australian therapeutic trial in mild hypertension. Report by the Management Committee. Lancet 1980;1(8181):1261-7 «PMID: 6104081»PubMed
  98. Blood Pressure Lowering Treatment Trialists' Collaboration. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis. Lancet 2021;397(10285):1625-1636 «PMID: 33933205»PubMed
  99. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 7. Effects of more vs. less intensive blood pressure lowering and different achieved blood pressure levels - updated overview and meta-analyses of randomized trials. J Hypertens 2016;34(4):613-22 «PMID: 26848994»PubMed
  100. Thomopoulos C, Parati G, Zanchetti A. Effects of blood-pressure-lowering treatment in hypertension: 9. Discontinuations for adverse events attributed to different classes of antihypertensive drugs: meta-analyses of randomized trials. J Hypertens 2016;34(10):1921-32 «PMID: 27454050»PubMed
  101. Thomopoulos C, Parati G, Zanchetti A. Effects of blood-pressure-lowering treatment on outcome incidence. 12. Effects in individuals with high-normal and normal blood pressure: overview and meta-analyses of randomized trials. J Hypertens 2017;35(11):2150-2160 «PMID: 28858984»PubMed
  102. Turnbull F, Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet 2003;362(9395):1527-35 «PMID: 14615107»PubMed
  103. Tzourio C, Anderson C, Chapman N, ym. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med 2003;163(9):1069-75 «PMID: 12742805»PubMed
  104. Verdecchia P, Staessen JA, Angeli F, ym. Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial. Lancet 2009;374(9689):525-33 «PMID: 19683638»PubMed
  105. Wald DS, Law M, Morris JK, ym. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med 2009;122(3):290-300 «PMID: 19272490»PubMed
  106. Warwick J, Falaschetti E, Rockwood K, ym. No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over. BMC Med 2015;13():78 «PMID: 25880068»PubMed
  107. Whelton PK, He J, Cutler JA, ym. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277(20):1624-32 «PMID: 9168293»PubMed
  108. Williamson JD, Supiano MA, Applegate WB, ym. Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial. JAMA 2016;315(24):2673-82 «PMID: 27195814»PubMed
  109. Wiysonge CS, Bradley H, Mayosi BM, ym. Beta-blockers for hypertension. Cochrane Database Syst Rev 2007;(1):CD002003 «PMID: 17253471»PubMed
  110. Wright JM, Lee CH, Chambers GK. Systematic review of antihypertensive therapies: does the evidence assist in choosing a first-line drug? CMAJ 1999;161(1):25-32 «PMID: 10420860»PubMed
  111. Wright JT Jr, Bakris G, Greene T, ym. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. JAMA 2002;288(19):2421-31 «PMID: 12435255»PubMed
  112. Yusuf S, Diener HC, Sacco RL, ym. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med 2008;359(12):1225-37 «PMID: 18753639»PubMed
  113. Zhang W, Zhang S, Deng Y, ym. Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension. N Engl J Med 2021;385(14):1268-1279 «PMID: 34491661»PubMed
  114. Zhang Y, Zhang X, Liu L ym. Is a systolic blood pressure target 140 mmHg indicated in all hypertensives? Subgroup analyses of findings from the randomized FEVER trial. Eur Heart J 2011;32:1500-8
  115. Zhong XL, Dong Y, Xu W, ym. Role of Blood Pressure Management in Stroke Prevention: A Systematic Review and Network Meta-Analysis of 93 Randomized Controlled Trials. J Stroke 2021;23(1):1-11 «PMID: 33600699»PubMed