Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment) and imprecise results (limited study size for each comparison).
A Cochrane review «Saline irrigation for chronic rhinosinusitis»1 «Chong LY, Head K, Hopkins C et al. Saline irrigat...»1 included 2 studies with a total of 116 adults. One study compared large-volume (150 ml) hypertonic (2%) saline irrigation with usual treatment over a 6-month period at the primary care setting; the other compared 5 ml nebulised saline twice a day with intranasal corticosteroids for 3 months and evaluating them on completion of treatment and 3 months later in a secondary care setting.