A Cochrane review «Tricyclic drugs for depression in children and adolescents»1 «Hazell P, Mirzaie M. Tricyclic drugs for depression in children and adolescents. Cochrane Database Syst Rev 2013;6():CD002317. . »1 included 14 studies with a total of 590 participants. No overall difference was found for the primary outcome of response to treatment compared with placebo RR 1.07, 95% CI 0.91 to 1.26; 9 trials, N = 454). Treatment with a tricyclic antidepressant caused more vertigo (RR 2.76, 95% CI 1.73 to 4.43; 5 trials, N = 324), orthostatic hypotension (RR 4.86, 95% CI 1.69 to 13.97; 5 trials, N = 324), tremor (RR 5.43, 95% CI 1.64 to 17.98; 4 trials, N = 308) and dry mouth (RR 3.35, 95% CI 1.98 to 5.64; 5 trials, N = 324) than did placebo,