A systematic review «Robinson J, Ferreira A, Iacovou M, et al. Effect of nutritional interventions on the psychological symptoms of premenstrual syndrome in women of reproductive age: a systematic review of randomized con»2 included 31 RCTs involving 3254 participants. Treatment with vitamin B6, calcium, and zinc consistently had positive effects on the psychological symptoms of PMS.
In a trial «Sharma P, Kulshreshtha S, Singh GM et al. Role of bromocriptine and pyridoxine in premenstrual tension syndrome. Indian J Physiol Pharmacol 2007;51(4):368-74. »1 60 patients were divided into 3 groups of 20 patients each - control group, bromocriptine group and pyridoxine group. In control group, patients were kept on ferrous sulphate tablet 100 mg for 3 months, as placebo. There was no significant change in the premenstrual symptoms score at the end of the study period in control group. Bromocriptrine 2.5 mg twice a day and pyridoxine 100 mg/day showed a significant reduction in the mean premenstrual symptom score after 3 months of treatment, and pyridoxine showed significantly higher response rate and lesser incidence of side effects than bromocriptine.
Comment: The quality of most studies was low.