A Cochrane review «Nonsteroidal anti‐inflammatory drugs for pain in women with endometriosis»1 «Brown J, Crawford TJ, Allen C et al. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev 2017;(1):CD004753. »1 identified two studies but only one with a total of 24 subjects was included in the analysis. Comparing NSAIDs (naproxen) to placebo, there was no evidence of a positive effect on pain relief (odds ratio (OR) 3.27, 95% CI 0.61 to 17.69) in women with endometriosis. There was also inconclusive evidence to indicate whether women taking NSAIDs (naproxen) were less likely to require additional analgesia (OR 0.12, 95% CI 0.01 to 1.29) or experience side effects (OR 0.46, 95% CI 0.09 to 2.47) when compared to placebo.
Comment: The quality of evidence is downgraded by imprecise results (few patients and wide confidence intervals) and generally too weak evidence for conclusions.