A Cochrane review «H1‐antihistamines for the treatment of anaphylaxis with and without shock»1 «Sheikh A, ten Broek V, Brown SG, Simons FE. H1-antihistamines for the treatment of anaphylaxis with and without shock. Cochrane Database Syst Rev 2007 Jan 24;(1):CD006160 [Review content assessed as u»1 included no studies. The authors found no randomized or quasi-randomized controlled trials comparing H1-antihistamines with placebo or no intervention in the treatment of anaphylaxis. These are likely to prove challenging to design and execute.