Last reviewed as up-to-date 4.9.2019 • Latest change 4.9.2019
Non-steroidal anti-inflammatory drugs are effective compared with placebo in reducing bleeding and pain associated with IUD use.
NSAIDs are recommended over no treatment for heavy menstrual bleeding in patients
with IUD and who wish to continue using non-hormone-releasing IUD and do not get sufficient
relief from tranexamic acid.
A Cochrane review «»1 «Grimes DA, Hubacher D, Lopez LM, Schulz KF. Non-st...»1 included 15 trials involving a total of 2 702 women from both developed and developing
countries. NSAIDs (naproxen, suprofen, mefenamic acid, ibuprofen, indomethacin, flufenamic
acid, alclofenac, and diclofenac) were effective in reducing menstrual blood loss
associated with IUD use. This held true for women with and without complaints of heavy
bleeding. NSAIDs were effective in reducing pain associated with IUD use. In contrast,
prophylactic use of NSAIDs had mixed results; studies with ibuprofen found no
effect on pain after insertion on IUD discontinuation. No important differences emerged
in the one trial comparing the effect of different NSAIDs on bleeding.
This document is linked to the following articles:
- Grimes DA, Hubacher D, Lopez LM, Schulz KF. Non-steroidal anti-inflammatory drugs
for heavy bleeding or pain associated with intrauterine-device use. Cochrane Database
Syst Rev 2006 Oct 18;(4):CD006034 [Last assessed as up-to-date: 17 August 2011]. «PMID: 17054271»PubMed
- «PMID: 23199413»PubMed