A Cochrane review «»1 «Grimes DA, Hubacher D, Lopez LM, Schulz KF. Non-st...»1 included 15 trials involving a total of 2 702 women from both developed and developing countries. NSAIDs (naproxen, suprofen, mefenamic acid, ibuprofen, indomethacin, flufenamic acid, alclofenac, and diclofenac) were effective in reducing menstrual blood loss associated with IUD use. This held true for women with and without complaints of heavy bleeding. NSAIDs were effective in reducing pain associated with IUD use. In contrast, prophylactic use of NSAIDs had mixed results; studies with ibuprofen found no effect on pain after insertion on IUD discontinuation. No important differences emerged in the one trial comparing the effect of different NSAIDs on bleeding.