Non-steroidal anti-inflammatory drugs for biliary colic

Summary

A Cochrane review «Non‐steroid anti‐inflammatory drugs for biliary colic»1 «Fraquelli M, Casazza G, Conte D et al. Non-steroid anti-inflammatory drugs for biliary colic. Cochrane Database Syst Rev 2016;(9):CD006390. »1 included 12 studies with a total of 828 subjects. When compared with placebo, NSAIDs obtained a significantly lower proportion of participants without complete pain relief (table «Non-steroidal anti-inflammatory drugs versus placebo/opioids/spasmolytic drugs for biliary colic»1), which was confirmed by Trial Sequential Analysis. NSAIDs showed more pain control than spasmolytic drugs (table «Non-steroidal anti-inflammatory drugs versus placebo/opioids/spasmolytic drugs for biliary colic»1), which was not confirmed by Trial Sequential Analysis. No difference was found in the proportions of participants without complete pain relief when comparing NSAIDs versus opioids (table «Non-steroidal anti-inflammatory drugs versus placebo/opioids/spasmolytic drugs for biliary colic»1). None of the included trials reported severe adverse events. Seven trials assessed non-severe adverse events: in 2, adverse events were not observed, and minor events were reported in the remaining 5 trials. There was no mortality.