A Cochrane review «Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in adults with cirrhosis and oesophageal varices»1 «Vadera S, Yong CWK, Gluud LL et al. Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in adults with cirrhosis and oesophageal varices. Cochrane Database S»1 included 6 studies with a total of 637 subjects. Included participants had cirrhosis and oesophageal varices with no previous history of variceal bleeding. Seventy-one of 320 participants allocated to band ligation compared to 129 of 317 participants allocated to no intervention died (RR 0.55, 95% CI 0.43 to 0.70; NNTTB = 6 persons). In addition, band ligation was associated with reduced risks of upper gastrointestinal bleeding (RR 0.44, 95% CI 0.28 to 0.72; 6 trials, 637 participants; NNTTB = 5 persons), serious adverse events (RR 0.55, 95% CI 0.43 to 0.70; 6 trials, 637 participants; NNTTB = 4 persons), and variceal bleeding (RR 0.43, 95% CI 0.27 to 0.69; 6 trials, 637 participants; NNTTB = 5 persons).
The non-serious adverse events reported in association with band ligation included oesophageal ulceration, dysphagia, odynophagia, retrosternal and throat pain, heartburn, and fever. No trials reported on health-related quality of life.
SOF table «https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012673.pub2/full#CD012673-sec1-0001»1
Abstract in McMaster database «Duodecim McMaster Plus References»McMaster