In a randomized controlled trial «Mellor R, Bennell K, Grimaldi A, et al. Education ...»1 education and exercise intervention reduced pain intensity of GTPS significantly more compared to wait and see approach. Pain intensity was measured on NRS 0-10 scale at baseline (4.8 vs 4.9), at 8 weeks (1.5 vs. 3.8) and at 52 weeks (2.1 vs 3.2). No serious adverse effects were reported. Quality of evidence is low due to risk of bias, imprecision and indirectness. Applicability of the evidence to Finland is average.
| Reference | Study type | Population | Intervention and comparison | Outcomes | Risk of bias |
|---|---|---|---|---|---|
| RCT=randomized controlled trial; SR=systematic review; MA=meta-analysis; NRS=Numerical Rating Scale | |||||
| «Mellor R, Bennell K, Grimaldi A, et al. Education ...»1 | RCT | Patients with clinically diagnosed GTPS | Exercise vs. wait and see | Primary: Pain intensity at 8 weeks and 52 weeks. Secondary: Clinically important pain reduction at 8 weeks and 52 weeks | High |
| Reference | Comments |
|---|---|
| «Mellor R, Bennell K, Grimaldi A, et al. Education ...»1 | Highly specific inclusion criteria. Intensive exercise program with 14 individualized physiotherapy sessions, home training and detailed advice/education. Due to the nature of the interventions blinding could not be performed. Low drop-out rates, no selective reporting. Use of additional treatments varied slightly between groups. |
Results
| Reference | Number of studies and number of patients (I/C) | Follow-up time | Reported mean pain (SD) I | Reported mean pain (SD) C | Adjusted mean difference (95% CI) |
|---|---|---|---|---|---|
| Level of evidence: low The quality of evidence is downgraded due to risk of bias, indirectness. I=intervention; C=comparison; CI=confidence interval; NRS=Numerical Rating Scale |
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| «Mellor R, Bennell K, Grimaldi A, et al. Education ...»1 | 1 (69/69) | 8 weeks | 1.5 (1.5) | 3.8 (2.0) | −2.2 (−2.89, −1.54) |
| Reference | Number of studies and number of patients (I/C) | Follow-up time | Reported mean pain (SD) I | Reported mean pain (SD) C | Adjusted mean difference (95% CI) |
|---|---|---|---|---|---|
| Level of evidence: moderate/low The quality of evidence is downgraded due to risk of bias, imprecision, indirectness. I=intervention; C=comparison; CI=confidence interval; NRS=Numerical Rating Scale |
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| «Mellor R, Bennell K, Grimaldi A, et al. Education ...»1 | 1 (69/69) | 52 weeks | 2.1 (2.2) | 3.2 (2.6) | −1.1 (−1.93, −0.33) |