Reduced perfusion pressure may be associated with the risk for glaucoma.
Systematic review
Although no causal relationship was proven in the review, the findings suggest that in patients with high baseline IOP, who already have a higher risk of glaucoma, low OPP might be another risk factor «Kim KE, Oh S, Baek SU ym. Ocular Perfusion Pressur...»1.
Thessaloniki Eye Study-study
Association of primary open-angle glaucoma and pseudoexfoliative glaucoma with ocular perfusion pressure status (ocular perfusion pressure with or without antihypertensive treatment) was studied in Thessaloniki Eye Study. Of the total of 2 554 randomly selected, ≥ 60-year old subjects participating in the study, only clinic-visit participants (n = 2 261), who had uniformly collected data, were included in the analyses. In the logistic regression model, the covariates included age, sex, diastolic ocular perfusion pressure, antihypertensive treatment, intraocular pressure (IOP), IOP-lowering treatment, pseudoexfoliation, and vascular factors identified as risk factors for glaucoma in a previous analysis. Among clinic-visits, 1 212 subjects (54%) were using antihypertensive treatment. An association of borderline significance was found between low diastolic ocular perfusion pressure and POAG (OR = 0.84 per 10 mm Hg, 95% CI = 0.70-1.01, P = .059). The effect of antihypertensive treatment on POAG was not statistically significant (OR = 1.20, 95% CI = 0.75-1.91, P = .45). In subgroup analyses, diastolic ocular perfusion pressure was significantly associated with POAG in subjects using antihypertensive treatment (OR = 0.78 per 10 mm Hg, 95% CI = 0.62-0.97, P = .028). No association was found between diastolic ocular perfusion pressure and PEXG, regardless of the use of antihypertensive treatment «Topouzis F, Wilson MR, Harris A ym. Association of...»2.