Systematic review 1
The ability of four prostaglandin analogies to lower intraocular pressure at least 30% from the baseline was investigated in comparison to timolol. As a result of the selection, 32 studies fulfilled the criteria. The probability for bimatoprost to lower the IOP was the highest (RR 1.59, CI 1.28–1.98), followed by latanoprost (RR 1.32, CI 1.00–1.74) and travoprost (RR 1.33, CI 1.03–1.72, and least probable was tafluprost (RR 1.1, CI 0.85–1.42) «Lin L, Zhao YJ, Chew PT ym. Comparative efficacy a...»1.
| RR | 95% CI | |
|---|---|---|
| Bimatoprost | 1.59 | 1.28–1.98 |
| Latanoprost | 1.32 | 1.00–1.74 |
| Travoprost | 1.33 | 1.03–1.72 |
| Tafluprost | 1.1 | 0.85–1.42 |
Systematic review 2
In a systematic review, different monotherapies were compared with each other among patients suffering from glaucoma and ocular hypertension. Altogether 114 articles fulfilled the preset criteria. In these articles the follow–up time was at least 3 months and they were published in 1983–2013.
The most effective drug class was prostaglandin analogs and a mean IOP reductions were «Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman...»2;
| Mean mmHg | 95% CI | |
|---|---|---|
| Bimatoprost | 5.61 | 4.94–6.29 |
| Latanoprost | 4.85 | 4.24–5.46 |
| Travoprost | 4,83 | 4.12–5.54 |
| Tafluprost | 4.37 | 2.94–5.83 |
| Timolol | 3.70 | 3.16–4.24 |
| Brimonidine | 3.59 | 2.89–4.29 |
| Brinzolamide | 2.42 | 1.62–3.23 |
| Dorzolamide | 2.49 | 1.85–3.13 |