Takaisin Tulosta

Brimodine and allergic reactions

Lisätietoa aiheesta
Glaucoma working group
28.3.2023

Brimonidine causes significantly more local allergic side effects than timolol

A meta-analysis from 2008 included 10 randomized clinical trials involving a total of 2387 patients. In all study settings, brimonidine 0.2% was compared to timolol 0.5% monotherapy for efficacy and adverse events. The age distribution of the data was 58-69 years and 60% had open-angle glaucoma and 37% had ocular hypertension.

Of the adverse reactions, local allergic reactions were statistically significantly less common in the timolol group than in the brimonidine group (RR 0.08, 95% CI 0.01-0.47). In contrast, there was no statistical difference in burning sensation and stinging between the groups.

Kirjallisuutta

  1. Loon SC, Liew G, Fung A ym. Meta-analysis of randomized controlled trials comparing timolol with brimonidine in the treatment of glaucoma. Clin Exp Ophthalmol 2008;36:281-9 «PMID: 18412600»PubMed