Takaisin Tulosta

Overview of all four randomised trials for adjuvant surgical bed radiation therapy after RP

Additional information
EAU guideline panel
16.4.2025
Table 1. Overview of all four randomised trials for adjuvant surgical bed radiation therapy after RP* (without ADT)
Study n Inclusion
criteria
Randomisation Definition of
BCR PSA (ng/
mL)
Median
FU (mo)
Biochemical
Progression-free survival
OS
*See Section 6.3.5.1 for delayed (salvage) post-radical prostatectomy external irradiation. BCR = biochemical recurrence; FU = follow-up; mo = months; n = number of patients; n.s. = not significant; OS = overall survival; PSA = prostate-specific antigen; RP = radical prostatectomy; SM = surgical margin; SRT = salvage radiotherapy.
SWOG 8794
2009 «Thompson IM, Tangen CM, Paradelo J ym. Adjuvant ra...»1
431 pT3 cN0 ±
involved SM
60–64 Gy vs.
observation
> 0.4 152 10 yr.: 53% vs.
30%
(p < 0.05)
10 yr.:
74% vs. 66%
Median
time:
15.2 vs. 13.3 yr., p = 0.023
EORTC
22911 2012 «Bolla M, van Poppel H, Tombal B ym. Postoperative ...»2
1,005 pT3 ±
involved SM
pN0 pT2
involved SM
pN0
60 Gy vs.
observation
> 0.2 127 10 yr.: 60.6%
vs. 41%
(p < 0.001)
81% vs.
77% n.s.
ARO 96-02
2014 «Wiegel T, Bartkowiak D, Bottke D ym. Adjuvant radi...»3
388 pT3 (±
involved SM)
pN0 PSA
post-RP
undetectable
60 Gy vs.
observation
> 0.05 +
confirmation
112 10 yr.: 56% vs.
35%
(p = 0.0001)
10 yr.:
82% vs.
86% n.s.
FinnProstate
Group 2019 «Hackman G, Taari K, Tammela TL ym. Randomised Tria...»4
250 pT2,R1/
pT3a
66.6 Gy vs.
observation
(+SRT)
> 0.4 (in 2
successive
measurements)
112 vs.
103
(patients
alive)
10 yr.: 82% vs.
61%
p < 0.001
10 yr.:
92% vs.
87% n.s.

References

  1. Thompson IM, Tangen CM, Paradelo J ym. Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial. J Urol 2009;181:956-62 «PMID: 19167731»PubMed
  2. Bolla M, van Poppel H, Tombal B ym. Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911). Lancet 2012;380:2018-27 «PMID: 23084481»PubMed
  3. Wiegel T, Bartkowiak D, Bottke D ym. Adjuvant radiotherapy versus wait-and-see after radical prostatectomy: 10-year follow-up of the ARO 96-02/AUO AP 09/95 trial. Eur Urol 2014;66:243-50 «PMID: 24680359»PubMed
  4. Hackman G, Taari K, Tammela TL ym. Randomised Trial of Adjuvant Radiotherapy Following Radical Prostatectomy Versus Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension. Eur Urol 2019;76:586-595 «PMID: 31375279»PubMed