Takaisin Tulosta

Absolute added values of targeted and systematic biopsies for ISUP grade ≥ 2 and ≥ 3 Cancer Detection

Additional information
EAU guideline panel
16.4.2025
ISUP>2 ISUP>3
*Intervals in parenthesis are 95% CI.
The absolute added value of a given biopsy technique is defined by the percentage of patients of the entire cohort diagnosed only by this biopsy technique.
ISUP = International Society of Urological Pathology (grade); MRI-TBx = magnetic resonance imaging-targeted biopsies; ND = not defined.
ISUP grade Cochrane meta-analysis*  «Drost FH, Osses DF, Nieboer D, ym. Prostate MRI, w...»1 MRI-FIRST trial*  «Rouvière O, Puech P, Renard-Penna R, ym. Use of pr...»2 4M trial  «van der Leest M, Cornel E, Israël B, ym. Head-to-h...»3 Cochrane meta-analysis*  «Drost FH, Osses DF, Nieboer D, ym. Prostate MRI, w...»1 MRI-FIRST trial*  «Rouvière O, Puech P, Renard-Penna R, ym. Use of pr...»2 4M trial «van der Leest M, Cornel E, Israël B, ym. Head-to-h...»3 
Biopsy-naïve Added value of MRI-TBx 6.3%
(4.8–8.2)
7.6%
(4.6–11.6)
7.0% (ND) 4.7%
(3.5–6.3)
6.0%
(3.4–9.7)
3.2% (ND)
Added value of systematic biopsy 4.3%
(2.6–6.9)
5.2%
(2.8–8.7)
5.0% (ND) 2.8%
(1.7–4.8)
1.2%
(0.2–3.5)
4.1% (ND)
Overall prevalence 27.7% (23.7–32.6) 37.5% (31.4–43.8) 30% (ND) 15.5% (12.6–19.5) 21.1% (16.2–26.7) 15% (ND)
Prior negative biopsy Added value of MRI-TBx 9.6%
(7.7–11.8)
- - 6.3%
(5.2–7.7)
- -
Added value of
systematic biopsy
2.3%
(1.2–4.5)
- - 1.1%
(0.5–2.6)
- -
Overall prevalence 22.8% (20.0–26.2) - - 12.6% (10.5–15.6) - -

References

  1. Drost FH, Osses DF, Nieboer D, ym. Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer. Cochrane Database Syst Rev 2019;4(4):CD012663 «PMID: 31022301»PubMed
  2. Rouvière O, Puech P, Renard-Penna R, ym. Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): a prospective, multicentre, paired diagnostic study. Lancet Oncol 2019;20(1):100-109 «PMID: 30470502»PubMed
  3. van der Leest M, Cornel E, Israël B, ym. Head-to-head Comparison of Transrectal Ultrasound-guided Prostate Biopsy Versus Multiparametric Prostate Resonance Imaging with Subsequent Magnetic Resonance-guided Biopsy in Biopsy-naïve Men with Elevated Prostate-specific Antigen: A Large Prospective Multicenter Clinical Study. Eur Urol 2019;75(4):570-578 «PMID: 30477981»PubMed