Takaisin

Itraconazole for fungal infections of the skin of the foot

Näytönastekatsaukset
Hannele Heikkilä and Ilona Mikkola
4.3.2021

Level of evidence: C

Itraconazole may be effective for fungal infection of the skin of the foot.

A Cochrane review «Bell-Syer SE, Khan SM, Torgerson DJ. Oral treatmen...»1 included 15 trials, involving 1438 participants of any age, who have a fungal infection of the skin of the foot that has been clinically diagnosed and confirmed by microscopy and growth of dermatophytes in culture. Only one trial (72 participants having moccasin type of tinea pedis) compared itraconazole with placebo (400 mg/day for one week). The exclusion criteria of the trial: no systemic agent 6 months before the start of the study.

Primary outcome was the mycological cure demonstrated by negative results on microscopy and no growth of dermatophyte in culture. One included trial showed that itraconazole was effective compared with placebo: RR 6.67, 95 % CI 2.17 to 20.48.

  • Study quality: High
  • Applicability: Good
  • Comment: The quality of evidence is downgraded by original trial's unclear (5/8) risk of bias.

References

  1. Bell-Syer SE, Khan SM, Torgerson DJ. Oral treatments for fungal infections of the skin of the foot. Cochrane Database Syst Rev 2012;10:CD003584 «PMID: 23076898»PubMed