The benefits of alcohol cessation are demonstrated «Schwarzinger M, Ferreira-Borges C, Neufeld M, ym. ...»1 in heavy drinkers even though light to moderate alcohol consumption is also associated to a small attributable fraction of oral cancer cases «Rumgay H, Shield K, Charvat H, ym. Global burden o...»2. The evidence comes from one large cohort study and is not either upgraded or downgraded.
Alcohol cessation advise and motivation should be targeted to all users and especially those having other risk factors or oral potentially malignant lesions.
| Reference | Study type | Population | Exposure | Outcomes | Risk of bias «Additional comments for included studies...»2 |
|---|---|---|---|---|---|
| «Schwarzinger M, Ferreira-Borges C, Neufeld M, ym. ...»1 | Cohort study | Cohort from French National Hospital Discharge database including acute, post-acute, and psychiatric day-case or inpatient hospital admissions and alcohol associated cancer diagnoses in France between 2018 - 2021 | Alcohol rehabilitation or history of abstinence | Oral cancer | moderate |
| Reference | Comments |
|---|---|
| «Schwarzinger M, Ferreira-Borges C, Neufeld M, ym. ...»1 | Included patients with alcohol dependence and heavy drinking diagnosis. Heavy drinking is explained as alcohol intake >60 g of pure ethanol per day (the equivalent of more than six alcoholic drinks per day) |
| Reference | Number of studies and number of patients (I/C) | Follow-up time | Relative effect (95% CI) |
|---|---|---|---|
| Level of evidence: low The quality of evidence is not downgraded or upgraded |
|||
| «Schwarzinger M, Ferreira-Borges C, Neufeld M, ym. ...»1 | exposure (alcohol rehabilitation or a history of abstinence) n=245 550
control (alcohol dependence without rehabilitation or abstinence) n=400 170 |
median follow up 3.8 y |
Men 0.63 (0.57–0.70) Women 0.59 (0.48–0.72) |
I= intervention; C=comparison; CI=confidence interval