The quality of evidence is downgraded due to study limitations and inconsistency.
Comment: Two meta-analyses were included. Although they partially include overlapping primary studies, they address different outcome definitions.
| Reference | Study type | Population | Intervention and comparison | Outcomes | Risk of bias «Overweight and obesity and risk of rheumatoid arthritis....»2 |
|---|---|---|---|---|---|
| SR=systematic review; MA=meta-analysis | |||||
| «Feng X, Xu X, Shi Y, et al. Body Mass Index and th...»1 | SR, MA | Adults. Europe, North America, and Asia. |
Observational studies (cohort, case-control). The association between BMI and rheumatoid arthritis risk. Comparison of overweight (25.0–29.9 kg/m²) and obesity (>30.0 kg/m²) versus normal weight (18.5–24.99 kg/m²). | Risk of rheumatoid arthritis (RA) | Low |
| «Ohno T, Aune D, Heath AK. Adiposity and the risk o...»2 | SR, MA | Adults. Europe and North America. | Cohort studies. The association between BMI and rheumatoid arthritis. Adiposity dose-response comparisons per 5 kg/m² BMI, per 5 kg/m² BMI at age 18, and per 10 cm waist circumference. |
Risk of rheumatoid arthritis (RA) | Low |
Results
| Reference | Number of studies and number of patients (I/C) | Absolute number of events (%) I | Absolute number of events (%) C | Relative effect (95% CI) |
|---|---|---|---|---|
| Level of evidence: low The quality of evidence is downgraded due to study limitations, inconsistency. I= intervention; C=comparison; CI=confidence interval |
||||
| «Feng X, Xu X, Shi Y, et al. Body Mass Index and th...»1 Overweight vs. normal weight Low |
16 total 406 584 |
N/A | N/A | RR 1.12 (1.04-1.20) |
| «Feng X, Xu X, Shi Y, et al. Body Mass Index and th...»1 Obesity vs. normal weight Low |
16 total 406 584 |
N/A | N/A | RR 1.23 (1.09-1.39) |
| Reference | Number of studies and number of patients (I/C) | Follow-up time | Absolute number of events (%) I | Absolute number of events (%) C | Relative effect (95% CI) |
|---|---|---|---|---|---|
| Level of evidence: low The quality of evidence is downgraded due to study limitations, inconsistency. I= intervention; C=comparison; CI=confidence interval; BMI= body mass index |
|||||
| «Ohno T, Aune D, Heath AK. Adiposity and the risk o...»2 Per 5 kg/m2 increase in BMI | 12 total 473 641 cases 4777 |
RR 1.11 (1.05–1.18) | |||
| «Ohno T, Aune D, Heath AK. Adiposity and the risk o...»2 Per 5 kg/m2 increment in BMI at age 18 years |
3 total 249 959 cases 1263 |
RR 1.17 (1.01–1.36) | |||